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doi: 10.1371/journal.pone.0097803 56 MeiningerVGengeAvan den BergLHRobberechtWLudolphAChioAet al

Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly

Epilepsy Res

miRNAs were also shown to be closely associated with the regulation of specific biological processes under combinatorial stresses

Cardiovascular (Heart and Blood Vessel) Complications In rare but serious cases, B12 replacement can lead to heart and blood vessel problems: Shortness of breath Peripheral edema (swelling in legs and arms) Rapid weight gain Pulmonary edema (fluid in lungs) Congestive heart failure (heart cannot pump effectively) Blood clots in vessels These complications arise from increased blood volume, thicker blood, and sudden changes in how hard the heart needs to work