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Andrade JG, Hawkins NM, Fordyce CB, Deyell MW, Er L, Djurdjev O, et al

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Improving the pharmacokinetic properties of peptides by increasing the metabolic stability (i.e., protection against degradation by proteases and peptidases), extending the biological activity (e.g., increased protein binding), increasing membrane association, and changing the tissue distribution and/or excretion rate (e.g., through self-aggregation) can overcome these problems

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Son mecanismos complementarios, por eso se estudian juntos