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Description
Recent preclinical and clinical data support the promise of several agents
Genet 19 , 5162 (2018)
One of them is GSK-3, a Ser/Thr protein kinase involved in several metabolic processes, including glycogen metabolism and insulin signalling [213]
Savolitinib is a novel and highly selective c-Met inhibitor, which has shown encouraging results in the phase III randomized clinical trial of papillary renal cell carcinoma (PRCC) (Gavine et al., 2015)
Additionally, metabolic profiling has revealed that suppression of GLS1 induces a compensatory anaplerotic mechanism via pyruvate carboxylase (PC), which allows the release of a glutamine-independent supply of TCA intermediates by catalyzing the transformation of pyruvate to oxaloacetate 153
