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Brain 139, 16801687

Author contributions SSa: Conceptualization, Writing review & editing, Data curation, Formal Analysis, Investigation, Methodology, Software, Validation

Similarly, a ketogenic diet has been demonstrated to activate AMPK in a nonsmall cell lung cancer model, which subsequently modulates the expression of the core circadian clock gene Bmal1

While the exact etiology of AD remains unclear, its development is linked to a range of factors, including genetic predisposition, abnormal protein aggregation, neurotransmitter imbalance and neuronal damage (46)

Melatonin mitigates oxidative stress, inflammation processes, and cell apoptosis by upregulating the Nrf2 signaling pathway and downregulating COX-2 protein levels (135), as well as SOD, GPx, CAT, and Bcl-2 activities (136)