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Frenkel B, Vered M, Taicher S, et al
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doi: 10.1016/j.trsl.2016.07.007
9,70 While first-generation MC4R agonists increased sympathetic tone, resulting in an increase in heart rate and blood pressure, uniquely, setmelanotide, a second-generation MC4R agonist, does not seem to have this effect
