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If these tests are nondiagnostic, genetic testing for LGMD, more common metabolic myopathies (eg, myophosphorylase, CPT2, myoadenylate deaminase deficiencies), and malignant hyperthermia susceptibility (eg, RYR1 and CACNA1S mutations) is recommended in the appropriate clinical context

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The uncommon epithelioid variant of MPNST arises from a pre-existing schwannoma and harbors SMARCB1 mutations [9, 11], whereas SMARCB1 has been reported to be intact in MMNST [13]

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