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Although routine B12 supplementation in patients on metformin therapy is not the standard of care (279), it is reasonable to monitor vitamin B12 levels in patients on metformin, particularly for individuals on long-term metformin (102

Their higher metabolic rate and training intensity can often tolerate higher doses

record source/lot, route, dose, and adverse events

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Switching to preservative-free formulations typically resolves the issue for people who need b12 but react to standard preparations