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Elkins P'21 Patricia Elkins P'21 Edward E

Hormonal fluctuations as a result of age and birth control can all contribute to the development of lax skin and excess fat around the midsection, and the appearance of a muffin top

The phosphorylated substrates that may be anchored to membrane fractions by adaptor proteins and/or directly bind active PKC once phosphorylated, may be released to the cytoplasm and act in the cytoplasm or they may translocate to the nucleus upon phosphorylation

The other patient developed endocrine dysfunction in the form of hypothyroidism, likely due to immunotherapy-induced thyroiditis, and a pathological bone fracture at a metastatic site, likely unrelated to study treatment