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There are many external factors contributing to hepatocellular injury, including insulin resistance (65), adipokine dysregulation (66), hepatic ATP depletion (67), uric acid-induced hepatocyte mitochondrial dysfunction (68), and the effects of intestinal microbiota products (69)

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Research has shown that a lack of LPL in microglia leads to an increase in LD accumulation [269]

Isoprenoids and Sterols The isoprenoids are branched lipids, also referred to as terpenoids , that are formed by chemical modifications of the isoprene molecule (Figure 4)

Reactive oxygen species mainly include O 2 .- and H 2 O 2 , which are physiologically generated as by-products of mitochondrial electron transfer