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[78] reported that fisetin can ameliorate type 2 diabetes-related vascular aging by targeting the PI3K/Akt/Bcl-2/Bcl-xl axis, promoting apoptosis of senescent endothelial cells, suppressing SASP factors, and enhancing the therapeutic efficacy of metformin, though direct dose equivalence and mechanistic comparisons were not established

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Ferroptosis mediated by mitochondrial VDACs VDACs are transmembrane channels that transport ions and metabolites and play an important regulatory role in ferroptosis 15

Enhanced glutathione production by a non-GMO Saccharomyces cerevisiae mutant isolated via acrolein resistance-mediated screening