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It is interesting to note that these systems are inactive during HOCl stress because of the oxidation of essential residues and the drop in intracellular ATP levels (Barrette et al., 1987

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Glutamine-addicted cells exhibit a decreased survival, or even undergo apoptotic cell death, associated with an increased in DNA damage, an overproduction of ROS or a decreased reduced/oxidized glutathione (GSH/GSSG) ratio