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In laboratory studies, synthetic BPC-157 is reported to

Multifactorial Intervention and Cardiovascular Disease in Patients with Type 2 Diabetes

Proceedings of the National Academy of Sciences, 101 (46), 1638516389

proposed a vascular normalization theory in which a judicious intensity of anti-angiogenic therapy could result in an equilibrium between anti-angiogenic and pro-angiogenic signals within the TMEvascular normalization statusand enable efficient delivery of oxygen, drugs, and anti-cancer immune cells into the tumor, rather than inducing excessive destruction of vessels and intratumoral hypoxia 35,36

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