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Superoxide Dismutase 1 and 2 Superoxide Dismutase (SOD) is an important antioxidant enzyme in organisms and the primary substance for scavenging ROS in the body, which is involved in the reaction of superoxide anion (O 2 ) and H + to produce H 2 O 2

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LeeSJSeoKWYunMRBaeSSLeeWSHongKWet al4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the akt/NF-kappaB signaling pathways

doi:10.2174/0115733971274700231226075717

Loss of GPX4 activity might activate other compensatory genes or pathways in response to increased ROS, such as FSP1 [42, 43]