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Infections: Certain infections, such as shingles or Lyme disease, can affect the nerves and cause symptoms like numbness or tingling in the limbs

The intramolecular disulfide bond between its two cysteine residues is believed to be important for maintaining its active conformation

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Another form of renal toxicity, generally associated with NSAIDs, is seen in patients with prerenal conditions leading to the reduction in renal blood flow or blood volume, where the renal prostaglandins have a supportive role in maintaining renal perfusion

Studies have also reported stimulation of proteoglycan and collagen synthesis in chondrocyte preparations, pointing to a meaningful role in joint research independent of its metabolic activity