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Pain relief and effectiveness may sometimes take time for the patient to notice the difference, however, it can last between 6 12 months and in some cases, years

However, this same mechanism is responsible for nausea, bloating, vomiting, and early satiety, especially when the body has not yet adapted to the drug

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10.1038/s41467-022-30559-2 258 ZhuL.WangZ.HanW.XuA

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