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Cheeseman KH, Holley AE, Kelly FJ, Wasil M, Hughes L, Burton G

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The mechanism may be related to curculigoside significantly reducing AD-promoting factors (e.g., A1-42, p-tau) and increasing ferroptosis protective factors (e.g., GPX4, SLC7A11, GSH) in the hippocampus and cortex of AD mice, 574 suggesting that the natural compound curculigoside can be used as a promising therapeutic agent to improve AD by inhibiting ferroptosis

Nerve growth factor (NGF), a member of the neurotrophin family, regulates pain perception in various acute and chronic pain conditions