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The pattern that warrants deeper investigation is this: multiple body systems are affected, conventional labs have returned normal, standard treatments havent produced lasting improvement, and symptoms may worsen in specific environments (home, office, or car) and improve when youre away

10.1038/s41467-021-24804-3 171 ZouL.ZhuD.GongM.YuJ

Aside from its role in catecholamine catabolism, COMT converts an antiestrogen compound (2-hydroxyestradiol) to a proestrogen (2-methoxyestradiol) and leads to an estrogen-rich environment

These findings align with previous reports indicating the maintenance of stem-cell-like cancer cells in established carcinoma cell lines [31]

Due to this unsatisfactory clinical application of glucocorticoids, there is an urgent need to develop novel strategies and therapeutics to treat ALI