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For example, postmenopausal women (aged 60+) treated with subcutaneous IGF1 at 15 g/kg twice daily showed increased whole-body and muscle protein synthesis though no change in strengthand GH-deficient adults saw increased lean mass with moderate effects on muscle strength (Pubmed) Mechanistic insights into IGF1 signaling A deep dive into molecular biology demonstrates how IGF1 activates the PI3K/Akt/mTOR pathways to boost protein synthesis, inhibit muscle breakdown, enhance satellite-cell regeneration, and suppress autophagysupporting its role in hypertrophy and repair PMC

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For recovery goals, track soreness, strength trends, mobility, workout readiness, and how long it takes to feel normal after training

Ser, Z., Liu, X., Tang, N

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