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Mechanistically, impaired FR-mediated folate uptake disrupts C1 metabolism, reducing methylation capacity and altering the expression of genes critical for synaptic formation, neuronal excitability, and neurotransmitter metabolism

Furthermore, the induction of PANoptosis via the PANoptosome complex prevents tumor escape mechanisms associated with single-pathway deficiencies (62)

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This guide covers the most researched peptides for brain repair, the mechanisms that make them effective, the clinical and preclinical evidence behind each one, and the practical considerations that matter for anyone exploring this rapidly evolving field