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For example, the NRF2-specific activator 4-octyl itaconate significantly reduces cisplatin-induced ferroptosis by activating the NRF2/HO-1 signaling pathway (Zhang et al., 2024)

Chen R, Lee WC, Fujimoto J, Li J, Hu X, Mehran R, Rice D, Swisher SG, Sepesi B, Tran HT, Chow CW, Little LD, Gumbs C, Haymaker C, Heymach JV, Wistuba II, Lee JJ, Futreal PA, Zhang J, Reuben A, Tsao AS, Zhang J

Leukemia 18(3):505-12, 2004

Diseases and pollutants disrupt these processes through altered ion transport, elevated pH and calcium, and goblet cell hyperplasia that leads to viscous mucus and airway obstruction

Identification of C-Terminal Amino Acid Residues of Rituximab In addition to its primary application of identifying isoAsp residues, this method demonstrated an added capability: the precise identification of C-terminal amino acids within proteins