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After 8 days, cultures exposed to hHGF or dimeric macrocycles developed branched tubules (Fig

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The coincident reduction in cellular antioxidant expression results in a reduced ability to counter oxidative stress and thus enhanced cellular damagea vicious cycle

The collective influence of multiple oncogenes on downstream potassium channels may promote K + flux via H + -sensitive KCN proteins

This inspires the development of a supramolecular binary vesicle, which is composed of p -sulfonatocalix[4]arene and enzyme-cleavable myristoylcholine that undergoes enzyme-induced disassembly triggered by the cholinesterase, thereby enabling in vitro controlled release of the AD drug tacrine and demonstrating potential for targeted drug delivery (Guo et al., 2012)