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Protandim supplementation prevented the loss of endothelium-dependent vasodilation in response to acetylcholine (ACh) in middle cerebral arteries (MCA) of HS-fed rats and hamster cheek pouch arterioles, and increased microvessel density in the cremaster muscle of HS-fed rats

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Neurogenic inflammation encompasses hyperemia, plasma protein extravasation, mediator release, and leukocyte infiltration and has been thought to contribute to a series of inflammatory diseases, including asthma and COPD
