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These findings support Ayahuasca-derived alkaloids as candidates for further investigation in neuroprotection and substance use disorder treatment.

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Elevated homocysteine and aberrant FOCM have also been reported in Amyotrophic Lateral Sclerosis, Multiple Sclerosis, and Huntingtons disease and are associated with neuroinflammation, demyelination, neuronal loss, and severe disease phenotypes in these conditions