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Nevertheless, the study fails to clarify differences in serum PCS levels among PBC patients at different disease stages, uses non-human primary Kupffer cells in vitro , and does not evaluate the safety threshold for clinical PCS supplementation, which limits its therapeutic translation
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doi: 10.1042/bj2290653 32 RigoniMPizzoPSchiavoGWestonAEZattiGCaccinPet al
In the hypermobile cases, collagen is altered in a way that allows tissue to be pulled beyond normal limits
