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Recent studies have shown that autosis in ischemia/reperfusion models is reduced by cardiac glycosides, which, by reducing the action of Na + -K + -ATPase, reduce its interaction with Beclin1

Furthermore, NRF2 enhances drug resistance by inducing the expression of ATP-binding cassette (ABC) transporters such as ABC sub-family C member 1 (ABCC1) and ABC sub-family G member 2 (ABCG2), which efflux chemotherapeutic agents out of cells

4.3 Manifestations of Se toxicity A study conducted in China showed that the lowest level of harmful effects observed for Se toxicity was 900-1000ug/day (115)

In terms of tumor dynamics, all tumor-bearing groups experienced tumor growth

In conclusion, astaxanthins role in reducing oxidative stress and regulating apoptosis signaling pathways offers a promising avenue for adjuvant treatment of neurodegenerative diseases
