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[16] After this initial phase, the frequency is reduced

Collectively, these studies indicate that modulation of NAD + levels affects additional critical cellular pathways other than mitochondrial homeostasis

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Other indications include malabsorption disorders (such as Crohn's disease or coeliac disease), following gastric surgery, strict vegan diets without supplementation, and certain medications that interfere with B12 absorption

And the difference between "fixing a real deficiency" and "megadosing when you're already fine" is the difference between a genuine improvement and expensive urine