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These approaches are powerful but have some limitations

84.Green JL, Heard KJ, Reynolds KM, et al

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Pan HY, Ye ZW, Zheng QW, Yun F, Tu MZ, Hong WG, Chen BX, Guo LQ, Lin JF (2022) Ergothioneine exhibits longevity-extension effect in Drosophila melanogaster via regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation

SARS-CoV-2 may activate TLR4 in the heart and lungs causing aberrant TLR4 signaling favoring the proinflammatory MyD88-dependent (canonical) pathway instead of the alternative TRIF/TRAM-dependent anti-inflammatory and interferon pathway (Aboudounya and Heads, 2021)