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Furthermore, their quinidinelike effect on cardiac conduction, which can prolong the QTc interval, necessitates careful cardiovascular screening and often precludes their use in elderly patients or those with preexisting heart disease, frequently positioning them as a secondary choice after SNRIs or gabapentinoids [45, 336, 368, 369]
National Natural Science Foundation of China (Grant numbers 72574038)
Similarly, Fig
acylamino and alkylamino refer to specific N-substituted organic radicals with acyl and alkyl substituent groups respectively
doi: 10.1016/j.molcel.2022.03.022 13 LyuYWangTHuangSZhangZ
