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Chen et al., 2022)

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The released DAG activates protein kinase C (PKC), while IP3 diffuses to the endoplasmic reticulum (ER) and binds to IP3 receptors on ligand-gated calcium channels on the surface of the ER, leading to a massive release of calcium ions into the cytosol [133]

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The concept of long-term stores is a simplification that overlooks the rapid metabolic turnover and the fact that a symptomatic patient may experience a swift decline in their well-being as the effects of the last injection wane

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