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64 (7), e02476-19
Epub 2011 Mar 31
Conclusions In conclusion, our findings demonstrate that VNS alleviates myocardial injury by reducing oxidative stress, mitochondrial damage, and ferroptosis in cardiomyocytes resulting from hepatic I/R injury
In addition, microglial plasticity to adopt an anti-inflammatory or pro-inflammatory phenotype is also altered as a consequence of age ( Several factors contribute to the acquisition by retinal microglia of a pro-inflammatory phenotype during ageing, including altered metabolism and reduced immunomodulatory signals from retinal neurons, such as the CX3CL1-CX3CR1 and CD200-CD200R signaling pathways, resulting in increased microglial activation ( As with microglial cells, astrocyte activation is also one of the hallmarks of physiological ageing (Nichols et al., 1993
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