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Furthermore, liposomes can degrade, destabilising their lipid bilayer structure, which results in the premature release of the encapsulated drug

Secondly, cereblon ligands have desirable physicochemical properties, including low molecular weight, lipophilicity, solubility, chemical and metabolic stability and the absence of pan-assay interference compound (PAINS) warnings 60

In this study, we employed a single-cell network approach to characterize malignant heterogeneity in gynecologic and breast cancers, focusing on the transcriptional regulatory mechanisms driving metabolic alterations

Table 1 Summary of association studies between genetic polymorphisms and outcomes in the cisplatin-based chemotherapy