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Buying b12 is a challenge and when NHS say they are going to cut patients off, it is a scary situation

Always follow the dosage instructions on the label or as advised by your healthcare provider
Importantly, it does not significantly stimulate ACTH, cortisol, or prolactin release at physiological doses (PMID: 9849822)

Signal transducer and activator of transcription (STAT) 3 inhibition delays the onset of lupus nephritis in MRL/lpr mice

However, the absence of large-scale human clinical trials means long-term safety data is still limited