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However, once the neuropathic pain was established, NS-398 showed no effect on pain behavior

Disease management involves supplementation with nicotinic acid or nicotinamide (75)

(584) used calcium imaging of nerve-mast cell signaling in the human intestine and found that roughly one-third of the mast cells in a given field of view responded with a sharp rise in intracellular calcium in response to stimulation of submucosal neurons
Gaudino, John J
NAVRAN, S.S
