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Intern Emerg Med 19 , 275293 (2024)

Lastly, while no significant difference was observed in the overall symptom score between groups, specific hyperthyroid symptoms were significantly lower in the intervention group, including irritability, tremor, mood lability, heat intolerance, and exertional dyspnea

Three metabolic pathways are known: - Glucuronidation (about 40% of the metabolism of the drug) - Sulfate conjugation (20-40%) - N-hydroxylation and rearrangement, then GSH conjugation (15%): the hepatic cytochrome P450 enzyme metabolizes the drug, forming a metabolite known as NAPQI (N-acetyl-p-benzo-quinone imine) that is irreversibly conjugated with sulphydryl group of glutathione

This molecule forms the foundations for many vital functions

Griffeth RJ, Bianda V, Nef S