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Description
S32 phosphorylation of RIPK1 prevents its activation and TNF-induced cell death To investigate the function of S32 phosphorylation in regulating RIPK1 activity and cell death, we reconstituted RIPK1-deficient MEFs with WT RIPK1, S32A mutant, and the phospho-mimetic S32E mutant
Altogether, these data support the hypothesis that G6PD-d drives ROS accumulation and may thereby amplify proinflammatory signaling or gene transcription in the absence of an acute stimulus 30
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