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Related to the Principle of Acid-Base Mediocrity is the Principle of Pressure Mediocrity (high pressure flows to low pressure, to give a mediocre pressure) and the Principle of Concentration Mediocrity (high concentration diffuses to areas of low concentration to give a mediocre concentration)

Eur J Clin Pharmacol 41, 1991

4a), whereas depletion of ETHE1 lowered it (Fig

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Treatment consists of replacement of kidney tubular losses, symptomatic management of systemic complications, and specific therapy directed at the basic defect, i.e., lysosomal cystine accumulation