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Nature 386 , 292296 (1997)
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Further, we report that environmental dysregulation of metabolism through saturated animal-based high-fat diet (HFD) and corticosterone results in a more aggressive disease progression

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This is one of the most efficient energy-producing pathways in cells, therefore, high energy demanding tissues, such as heart and kidney, mainly rely on fatty acids utilization (Hanahan and Weinberg, 2011)
