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found that TNF treatment of human OLs in culture induces apoptosis-inducing factor mitochondria associated 1 (AIF)-mediated cell death, also known as parthanatosis, involving hyperactivation of DNA damage response machinery 54

J Assoc Nurses AIDS Care 2010;21:1624

[DOI] [PubMed] 199.Poorshiri B, Barzegar M, Tahmasebi S, Shiva S, Raeisi S, Ebadi Z

Optimized quantities of GDNF overexpressed by engineered astrocytes are critical for protection of neuroblastoma cells against 6-OHDA toxicity

A double-blind, placebo-controlled trial could be helpful in exploring these questions (of note, the authors of this paper are currently conducting a clinical trial with secondary and exploratory outcomes aimed to explore symptomatic benefits, NCT04584346)