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Indeed, terminally differentiated neurons rely on efficient quality control systems such as the autophagic-lysosomal pathway for maintaining their delicate proteostasis, which is gradually impaired as the brain ages (Figure 1A)

They achieve this by binding to the mRNA transcripts of these proteins, which inhibits their translation into functional proteins

Proteomic profiling Arl6 / and WT cilia proteins were compared after APEX labeling in triplicate

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We maintained the stoichiometric ratio of Fe: Se at 1:2