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Description
Larsson , Kamaluddin Latief , Sum Yuet Joyce Lau , Matthew B
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, leads to altered carbohydrate metabolism in cancer cells
The decreased expression and signaling of TLRs, essential for recognizing pathogen-associated molecular patterns (PAMPs), further impair the ability of aging macrophages to phagocyte apoptotic cells and respond to pathogens
Current laboratory trials are investigating the synergistic potential of this combination
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