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Among them, the most clinically successful NRF2 activator is dimethylfumarate (DMF), authorized in Germany in 1994 for the treatment of psoriasis [281]

Discussion Oxidative stress is caused by the imbalance between levels of ROS and antioxidants in cells and tissues 24

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However, its presence in other subcellular localizations such as the plasma membrane, mitochondria, or nucleus raises the question whether HO could exert some protein-protein or protein-DNA interactions that could play other roles, such as transcriptional regulation, which requires further exploration

[DOI] [PMC free article] [PubMed] [Google Scholar] 434.Hensley K., Benaksas E.J., Bolli R., Comp P., Grammas P., Hamdheydari L., Mou S., Pye Q.N., Stoddard M.F., Wallis G., et al