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Astrocytes also function as glycogen reservoirs, storing glucose and mobilizing it in response to increased neuronal activity 68

Mice were housed at the University of North Texas Health Science Center and are hereafter referred to as MitoQC mice

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Expression of histamine degrading enzymes in porcine tissues

Promising results have also been reported by two recent studies of metformin in combination with TKIs and ICIs, respectively, which suggested that metformin was able to significantly improve PFS and OS in patients with NSCLC by overcoming acquired resistance to TKIs and enhancing PD-1 blockade by anti-PD-1 antibodies, respectively (101,102)