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Overexpression of SIRT3 decreases HCC cell proliferation and promotes apoptosis through multiple mechanisms, including the activation of the GSK-3/Bax signalling pathway [196], upregulation of p53 [198], and reduction in Mdm2-mediated p53 degradation [199]

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However, upon cold stress treatment to leaves of thermo-tolerant E

As the main methyl donor in cells, SAM also mediates a variety of methylation reactions, aside from DNA methylation, including histone, RNA, and some protein amino acid residue methylation (Teperino et al., 2010)

[DOI] [PMC free article] [PubMed] [Google Scholar] 206.Franzoni F., Scarfo G., Guidotti S., Fusi J., Asomov M., Pruneti C