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Activation of AMPK by upstream kinases phosphorylates target enzymes, such as acetyl-coA carboxylase (ACC), leading to inhibition of lipogenic pathways and activation of FA oxidation 22

Vitamin B6 may also reduce the risk for blood clotting and eye and bone problems

Thus, reductive stress induced by altered ratios of these three redox couples affects cellular metabolism and vice versa

Although Shults et al

first proposed the concept of oxidative stress, either caused by an increase in free radical production or a reduction in the scavenging capacity of the body, leading to disorders in the oxidation and antioxidant systems, resulting in oxidative damage by free radical accumulation (Sohal and Allen, 1990)