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This method involves three enzymes (TET2, T4-BGT and APOBEC3A) and two chemical reactions: firstly, DNA is treated with TET2 and T4-BGT so that 5mC and 5hmC could not be deaminated, and secondly, APOBEC3A is used for deaminating the remaining unmodified cytosines [89]

Simon JA, Hudes ES

The mitochondrial inner-membrane protein PiC2 (SLC25A3) can bind copper ions and acts as a mitochondrial copper transporter, delivering copper into the organelle and promoting the metallation of cytochrome c oxidase (CCO) in eukaryotic cells (49)

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For complete information about potential drug interactions, consult the Prescribing Information in Canada: and discuss any concerns with your healthcare provider