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However, in AS, cardiac hypertrophy, HF and ischemia-reperfusion injury (99,112,121,128), the protective function of the PI3K/AKT pathway is impaired or insufficiently upregulated, making it an ally that requires activation

normal insulin response to glucose load) Decreased glucose tolerance (fasting blood glucose: normal

Collectively, these results indicate that LIG (Na) alleviates DIC by PIEZO1-dependent restoration of mitochondrial dynamic balance and mitophagy-UPR mt synergy, ultimately rescuing respiratory chain functionality and bioenergetic metabolism [34]
10.1073/pnas.0500268102