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410 As a result, nanoparticles with dimensions in the 50200 nm range can readily extravasate into the tumor interstitial space (permeation) and remain there (retention) releasing their contents into the extracellular space of the tumor microenvironment or being taken up by cancer cells

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Feldman HA, Erasmus JJ, Zhou N, Antonoff MB, Mehran RJ, Rajaram R, Rice DC , Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Hofstetter WL, Betancourt Cuellar SL