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Vivani is developing an implantable GLP-1 product candidate designed for reversible 6-12 month dosing with steady PK that may also mitigate tolerability issues

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10.1038/s41467-019-13896-7 [DOI] [PMC free article] [PubMed] [Google Scholar] 208.Rao A, Barkley D, Frana GS, Yanai I

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Electron microscopy studies reveal that rats pretreated with SS-31 maintain intact cristae membranes and normal mitochondrial morphology throughout 45 minutes of renal ischemia and subsequent reperfusion, while untreated animals show dramatic mitochondrial swelling, cristae loss, and disrupted outer membranes consistent with mitochondrial permeability transition