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Exercise robustly improves mitochondrial function, endothelial health, and myokine-mediated cross-talk between muscle, adipose tissue, and the brain, while vitamin D, acting through the vitamin D receptor (VDR), modulates calcium homeostasis, immune signaling, and tissue-specific metabolic responsiveness

-glutamylcysteine ameliorates oxidative injury in neurons and astrocytes in vitro and increases brain glutathione in vivo

Overall, BioLure is a versatile tool for understanding the intracellular delivery process on live cells, and establishing the link between the cytosolic concentration of intracellularly-delivered biotherapeutics and their therapeutic efficacy

Clinical success (survival without major complications) was observed in 49.6% (n = 231)