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Previous studies showed that reduced fatty acid oxidation and increased lipid accumulation promote nuclear translocation of DVE-1 and ATFS-1, 45 which not only activate genes related to mitoUPR but also upregulate the metabolic regulator nhr-80 , 46 which in turn activates the diacylglycerol acyltransferase dgat-2 to promote TAG synthesis 46 and upregulates fatty acid desaturases fat-5 and fat-7 to promote PUFA production

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